sustained EB-2 NIW Case: Cardiovascular Medicine

U.S. Citizenship 
and Immigration 
Services 
MATTER OF K-H-S-
APPEAL OF TEXAS SERVICE CENTER DECISION 
Non-Precedent Decision of the 
Administrative Appeals Office 
DATE: JUNE 7, 2017 
PETITION: FORM I-140, IMMIGRANT PETITION FOR ALIEN WORKER 
The Petitioner, a researcher who investigates molecular treatments for cardiovascular disease, seeks 
second preference immigrant classification as a member of the professions holding an advanced 
degree, as well as a national interest waiver of the job offer requirement attached to this EB-2 
classification. See Immigration and Nationality Act (the Act) section 203(b)(2), 8 U.S.C. 
§ 1153(b)(2). After the petitioner has established eligibility for EB-2 classification, U.S. Citizenship 
and Immigration Services (USCIS) may, as matter of discretion, grant a national interest waiver if 
the petitioner demonstrates: (1) that the foreign national's proposed endeavor has both substantial 
merit and national importance; (2) that the foreign national is well positioned to advance the 
proposed endeavor; and (3) that, on balance, it would be beneficial to the United States to waive the 
requirements of a job offer and thus of a labor certification. Matter of Dhanasar, 26 I&N Dec. 884 
(AAO 2016). 
The Director of the Texas Service Center denied the petition, finding that the Petitioner did not 
qualify for classification as an individual of exceptional ability, or establish that a waiver of a job 
offer would be in the national interest. The Director did not address the Petitioner's eligibility as a 
member of the professions holding an advanced degree. 
The matter is now before us on appeal. In his appeal, the Petitioner asserts that the Director 
"misapplied or ignored" the relevant law resulting in an abuse of discretion. He maintains that he 
qualifies as an advanced degree professional and that he is eligible for the waiver based upon the 
significance ofhis research in cardiovascular medicine. 
Upon de novo review, we will sustain the appeal. 
I. LAW 
To establish eligibility for a national interest waiver, a petitioner must first demonstrate qualification 
for the underlying EB-2 visa classification, ~s either an advanced degree' professional or an 
individual of exceptional ability in the sciences, arts, or business. Because this classification 
requires that the individual's services be sought by a U.S. employer, a separate showing is required 
to establish that a waiver of the job offer requirement is in the national interest. 
Matter of K-H-S-
Section 203(b) ofthe Act sets out this sequential framework: 
(2) Aliens who are members of the professions holding advanced degrees or aliens of 
exceptional ability. 
(A) In general. - Visas shall be made available ... to qualified immigrants who 
are members of the professions holding advanced degrees or their equivalent or 
who because of their exceptional ability in the sciences, arts, or business, will 
substantially benefit prospectively the national economy, cultural or educational 
interests, or welfare of the United States, and whose services in the sciences, arts, 
professions, or business are sought by an employer in the United States. 
(B) Waiver of job offer-
(i) National interest waiver. ... [T]he Attorney General 1 may, when the 
Attorney General deems it to be in the national interest, waive the 
requirements of subparagraph (A) that an alien's services in the sciences, arts, 
professions, or business be sought by an employer in the United States. 
While neither the statute nor the pertinent regulations define the term "national interest," we recently 
set forth a new framework for adjudicating national interest waiver petitions. See Dhanasar, 26 I&N 
Dec. 884.2 Dhanasar states that after EB-2 eligibility has been established, USCIS may, as a matter 
of discretion, grant a national interest waiver when the below prongs are met. 
The first prong, substantial merit and national importance, focuses on the specific endeavor that the 
foreign national proposes to undertake. The endeavor's merit may be demonstrated in a range of 
areas such as business, entrepreneurialism, science, technology, culture, health, or education. In 
determining whether the proposed endeavor has national importance, we consider its potential 
prospective impact. 
The second prong shifts the focus from the proposed endeavor to the foreign national. To determine 
whether he or she is well positioned to advance the proposed endeavor, we consider factors 
including, but not limited to: the individual's education, skills, knowledge and record of success in 
related or similar efforts; a model or plan for future activities; any progress towards achieving the 
proposed endeavor; and the interest of potential customers, users, investors, or other relevant entities 
or individuals. 
1 Pursuant to section 1517 of the Homeland Security Act of 2002 ("HSA"), Pub. L. No. I 07-296, 116 Stat. 2135, 2311 
(codified at 6 U.S.C. § 557 (2012)), any reference to the Attorney General in a provision of the Act describing functions 
that were transferred from the Attorney General or other Department of Justice official to the Department of Homeland 
Security by the HSA "shall be deemed to refer to the Secretary" of Homeland Security. See also 6 U.S.C. § 542 note 
(2012); 8 U.S.C. § 1551 note (2012). 
2 
In announcing this new framework, we vacated our prior precedent decision, Matter of New York State Department of 
Transportation, 22 I&N Dec. 215 (Act. Assoc. Comm 'r 1998) (NYSDOT). 
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Matter of K-H-S-
The third prong requires the petitioner to demonstrate that, on balance, it would be beneficial to the 
United States to waive the requirements of a job offer and thus of a labor certification. In 
performing this analysis, US CIS may evaluate factors such as: whether, in light of the nature of the 
foreign national's qualifications or the proposed endeavor, it would be impractical either for the 
foreign national to secure a job offer or for the petitioner to obtain a labor certification; whether, 
even assuming that other qualified U.S. workers are available, the United States would still benefit 
from the foreign national's contributions; . and whether the national interest in the foreign national's 
contributions is sufficiently urgent to warrant forgoing the labor certification process. In each case, 
the factor(s) considered must, taken together, indicate that on balance, it would be beneficial to the 
United States to waive the requirements of a job offer and thus of a labor certification. 3 
II. ANALYSIS 
The Petitioner's research focuses on the application of molecular biology to the treatment of 
cardiovascular disease. The Director did not address the Petitioner's asserted eligibility as a member of 
the professions holding an advanced degree, and instead evaluated his qualifications as an individual of 
exceptional ability. The record includes evidence that, in 2011, the Petitioner earned the equivalent of a 
PhD from the Taiwan.4 Thus, we find that he is eligible 
under this classification as a member of the professions holding an advanced degree. 5 The remaining 
issue in contention is whether the Petitioner has established that a waiver of the job offer requirement, 
and thus a labor certification, is in the national interest. 
A. Substantial Merit and National Importance of the Proposed Endeavor 
At the time of filing the petition, the Petitioner indicated he was employed as a postdoctoral researcher 
at Maine, where he focused on cardiovascular medicine. 6 The 
Petitioner explained that he plans to continue his cardiovascular research into improving 
cardiovascular functioning and developing innovative treatments for heart disease and stroke. He 
stated that he aims to "characterize new pathways to induce endothelial nitric oxide release, thereby 
benefiting endothelial-related cardiovascular diseases and atherosclerosis," while developing "specific 
molecular targets" in the battle to "treat and cure" cardiovascular diseases. The Petitioner submitted 
reports describing how endothelial cell-related vascular dysfunctions are fundamentally linked to 
cardiovascular disease development, which is a leading cause of death around the world. We find that 
the Petitioner's proposed work has s~bstantial merit because it aims to improve understanding of novel 
therapeutic and pharmacological avenues of treatment for cardiovascular diseases. 
3 See Dhanasar, 26 I&N Dec. at 888-91, for elaboration on these three prongs. 
4 The record includes a copy of an evaluation of educational credentials indicating that the Petitioner's degree is the 
equivalent of a PhD in the field of physiology awarded by an accredited institution of higher education in the United 
States. 
5 As the Petitioner is already eligible for the underlying immigrant classification as a member of the professions holding 
an advanced degree, an additional finding of exceptional ability would serve no meaningful purpose in this matter. 
6 
USCIS records indicate the National Institute of Health (NIH) has subsequently sponsored the Petitioner for a 
nonimmigrant H-1 8 visa, though the record does not include additional evidence of the Petitioner's current employment. 
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Matter of K-H-S-
The record also demonstrates that the Petitioner's proposed endeavor is of national importance. The 
Petitioner provided letters from colleagues and independent researchers in the field describing the 
importance of developing molecular and genetic based treatments for cardiovascular disease and 
discussing how clinicians and researchers rely upon comprehensive evidence-based molecular data 
as the critical factor to understanding hemi disease and treating patients. The letters explain that the 
. Petitioner's proposed work developing molecular pathways for treating cardiovascular disease stands to 
improve the quality of disease prevention and treatment, thereby alleviating the formidable cost of the 
disease to individuals and the economy. In .addition, the Petitioner has submitted documentation 
indicating that the proposed benefit of his research has broader implications for his field, as the 
results from his work are disseminated to others through medical journals and conferences. As the 
Petitioner has documented both the substantial merit and national importance of his proposed 
research, he meets the first prong of the Dhanasar framework. 
B. Well Positioned to Advance the Proposed Endeavor 
The Petitioner submitted his resume, educational credentials, documentation of published and 
presented work, evidence of peer review activities, and reference letters discussing his work in the 
field .. As discussed below, we find that the Petitioner's notable experience on projects that have 
attracted considerable interest in the area of cardiovascular disease and his past success in performing 
influential original research render him well positioned to advance the proposed endeavor. 
Several of the submitted letters address the significance of the Petitioner's past work related to the 
_ _ . , which mediates the production of red blood cells. For 
example, Dr. a professor at China, notes that the 
Petitioner has made vital discoveries to understanding cardia-protective effects against foam cell 
formation. Dr. explains that the Petitioner "provided an absolutely outstanding experimental 
method for oxidately modified low-density lipoprotein formation" which he used in several of his own 
studies, reflecting "the deep and lasting impact of [the Petitioner's] contributions" to his work. Dr. 
also describes how he has employed the Petitioner's methods for using liver receptors to determine 
efficacy against atherosclerosis. He notes that the Petitioner's protocols and experimental 
strategies have been "indispensable" to his own research, helping him "reach some central 
conclusions." He attests that the Petitioner's methods contain an "uncommon clarity" and that "other 
researchers have greatly benefited from implementing [his] work." 
Dr. . co-founder and chief scientific officer at testifies that the 
Petitioner's work has established that the beta common receptor is critical to endothelial nitric oxide 
synthase activity. He attests that this work "has actively influenced the way investigators structure their 
experiments" making his contributions "markedly significant to the field at large." Dr. also 
states that the Petitioner's research "helped me explain my experimental observations" reflecting the 
"major importance of his novel contributions." Finally, he comments that he recognized the Petitioner's 
research in his review entitled ' ," in which he 
commended the Petitioner for clarifYing ·how beta common receptor is implicated in nitric oxide 
production associated with tissue repair. Dr. explains that his "consistent references" to the 
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Matter of K-H-S-
Petitioner's work "signifY his belief' in the "major importance of [his] work within the field." 
Similarly, Dr. , assistant professor at the lauded the 
Petitioner's research outlining effect on endothelial cells and atherosclerosis. He explains that 
the Petitioner's results "pinpoint" agents in signaling, finding that "treatment with decreased 
oxidized low-density lipoprotein-treated macrophage lipid accumulations." He notes that the 
Petitioner's work has been adopted by researchers around the globe and that it has "mass cross­
disciplinary applicability." 
Finally, several letters attest to the positive impact of the Petitioner's studies on the effects of in 
atherosclerosis, noting that his work has had a "major influence" on the cardiovascular medicine field, 
directly shaping the methods researchers employ and enabling them to validate their resulting data. Dr. 
an assistant professor at , Turkey, explains that "[the 
Petitioner's] work on endothelial cells greatly benefits further drug developments, which provide easier 
more cost effective means for treating deadly diseases." He notes that the Petitioner's work has been 
directly used by other prominent researchers as a "cornerstone" for furthering their work in 
cardiovascular disease management. Similarly, Dr. a professor at 
School of Medicine provided a detailed review and commendation of the Petitioner's results on the 
effects of on red blood cell production. 
Supporting the above statements, the record includes documentation of numerous peer reviewed 
journal articles that the Petitioner has written or co-written and that have been extensively and 
consistently cited7 by independent experts in the field, affirming the acceptance and use of the 
Petitioner's work. 8 He has also offered several letters of recommendation from independent 
evaluators who confirm that his work has generated a high degree of positive interest from the 
broader medical community. Several of these individuals testify that they have modified their 
protocols based upon his research and publications. Overall, the Petitioner has demonstrated through 
his scholarship, innovative methodologies, and record of high citations, that he has a record of success 
and progress in his field, and that his work has attracted the sustained interest of relevant parties at a 
level that renders him well positioned to advance his proposed endeavor of researching molecular 
treatments for cardiovascular disease. 
C. Balancing Factors to Determine Waiver's Benefit to the United States 
Third.and finally, we conclude that, on balance, it would be beneficial to the United States to waive 
the requirements of a job offer and thus of a labor certification. As noted above, the Petitioner holds a 
PhD in physiology, along with considerable experience and expertise researching the molecular 
7 The record reflects that, at the time of filing, the Petitioner's work had been cited a total of 426 times and that many of 
his articles were among the top 10% in the field by respective year of publication. 
8 The Director noted that one of the journals publishing the Petitioner's research requires a manuscript processing fee and 
an open access fee, making it appear that "any researcher can have his article published." On appeal, the Petitioner 
explains that these fees only provide free access to an author's work on the journal's website, which is a voluntary option 
for authors whose manuscripts have already been accepted. The Petitioner maintains that these fees have no bearing on 
whether an article will be accepted for publication. 
5 
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Matter of K-H-S-
foundations of cardiovascular disease. The Petitioner has documented his past success developing new 
experimental methods that have been recognized and utilized by other scholars in his field. Experts 
have consistently applauded the Petitioner's contributions relating to mediation of red blood cells, 
along with his development of a unique cholesterol efflux method, and his work has been cited by other 
researchers indetailed reviews. He has also presented evidence that his methods have directly led to 
further substantive investigation and innovation in both the public and the private sector. For these 
reasons, we find the P~titioner has established that the United States will benefit from his 
contributions even assuming that other qualified U.S. workers were available to perform these 
critical functions. Therefore, we conclude that, on balance, it would be beneficial to the United States 
to waive the requirements of a job offer and thus of a labor certification. 
III. CONCLUSION 
The Petitioner has met the requisite three prongs set forth in the Dhanasar analytical framework. We 
find that he has established eligibility for and otherwise merits a national interest waiver as a matter 
of discretion. 
ORDER: The appeal is sustained. 
Cite as Matter of K-H-S-, ID# 532240 (AAO June 7, 2017)